Effects of Zanthoxylum acanthopodium on MMP-9 and GLUT-1 expression and histology changes in rats with cervical carcinoma

Cervical cancer is one of the most common cancers in Indonesia. It can be treated with molecular therapies targeting Matrix metallopeptidase 9 (MMP-9) and Glucose transporter (GLUT-1), which are enzymes that involved tumour cell invasion, metastasis angiogenesis. Zanthoxylum acanthopodium (andaliman) an Indonesian herb anti-cancer properties. This study aimed to investigate histological changes andaliman treatment caused MMP-9 GLUT-1 expression. used five groups rats: control (C-), model (C+), cancer-bearing rats a 100-mg dose methanol extract (ZAM)/BW (ZAM100), 200-mg ZAM /BW (ZAM200) 400-mg ZAM/BW (ZAM400). Immunohistochemical methods were stain cervical tissue antibodies, TUNEL assay was performed apoptosis. administration did not affect rat body weight but had significant effect on growth. There increase MDA levels associated SOD deficiency tissue. activity increased due administration, allowing cells protected from oxidant disruption oxidative stress. ameliorated carcinoma damage reduced expression MMP-9, apoptosis serum ( p < 0.01) In short, higher dose, lower apoptosis, indicating effective treat cancer.